This article was first publised in the "Romanian Anti Aging Magazine":
"Cutaneous aging it`s a slowly process , that starts it`s clinical change perfidious after the age of 35.
The mainly cause of cutaneous ageing process is the accumulation of superoxyds (free acids) : superoyds ions, the hydroxide anion, peroxide of hydrogen and the singhalet oxygen.
The free radicals can appear after the cells oxidoreduction process during the human body normal methabolism, but also they can appear after exhibiting to environment pollution, noxas, smoking, uV radiations, alchool and drugs consmption, after swells.
The cutaneous ageing is the consequence of two processes : the extrinsic ageing ( photo ageing) and the intrinsic ageing ( the chronological one).
The chronological one has a genetic propensity. The ageing skin is clinical characterised by losingit`s normal texture, tonus, resilence and firmness. The skin becomes thin, translucid and that makes possible seeing the underneath dilated vessels, that lost their resilience: teleangiectasia.
It becomes dryed, serous because of the substraction of sebaceous and sudoriparous secretion with an important role for maintaining the protective, hidrolipidic lubricant cutaneous film that ensures skin`s flexibility.
It has a pigmentation which is not homogenous - through the appearance of the lentigo, actinic Keratosis and seborrhoeic Kerastosis especially when one expose to the sun radiations.
After that we can see the wrinkles: expression wrinkles and then the deep ones. After losing the hypodermic grease the cheeks and the eyes widen, the eyelids fall, it appears the goitre, the superiour lip becomes thin, the skin looks flabby, depened, and we can see grossly and vertical wrinkles arond the lips.
The clinical manifestations are the consequence of the next pathological changes:
- at the epidermic level the capacity of cells renovation goes down, the epiderm is thin.
- the dermic level is characterised by the decrease of the collagen and elastic fibras which is caused by fibroblasts and growth of colagenosis and methaloproteinasis activity, and also growth of glycosided collagen the cause for cells death, the derm is atrophied.
- the pigmentattion changes are the consequence of the lipofuscines accumulation in fibroblasts and the oresence of melanic cells at the demo-epidermial junction.
The causative for the superficial wrinkles is the elastic fibras deterioration.
The expression wrinkles are the consequence of facial repeated movement with the secondary and frequency contractions of facial muscles, and from the morfo-pathological point of view it`s the densification of dermoepidermical junction.
The deep wrinkles are caused by the deterioration of the elastic fibras.
The gravitational wrinkles appear after losing the resilence of the skin and of the cellular hypodermic tissue the adipose tissue is slided, and the derm is relaxed."
Romanian Anti Aging Magazine
